The Royal Philanthropic Expedition of the smallpox vaccine was ordered by King Charles IV of Spain (1748 1819) and was a public health project deployed in the Spanish colonies in America and Asia. The military doctors Francisco Xavier Balmis and Josep Salvani Lleopard led the expedition. He left the port of La Coruña on November 30, 1803 in the corvette María Pita. Dr. Balmis offered his services to the crown in order to carry out the smallpox vaccine in America and the Philippines. The expedition arrived in Puerto Rico, La Guaira, Puerto Cabello, Caracas, Havana, Merida, Veracruz and Mexico City. The vaccine reached places as far away as Texas in the north and New Granada in the south. Nevertheless, other members of his expedition took the vaccine to South America, to Chiloé (in the current Republic of Chile), including Dr. Salvany. In September 1805 they sailed towards Manila and in 1806 they returned to Spain. On his return trip he still spread the vaccine through Macao and Canton (China) and on the island of Santa Elena, an English land in the South Atlantic. It was the first world expedition of the vaccine and it went around the world.