Spanish government representative and dignitary of the Kingdom. Son of Ignacio Pérez Caro de Oviedo and María Catalina Campuzano-Polanco Fernández. In 1795, his family moved to Havana as a result of the entry of the French into Santo Domingo. He obtained his bachelor's degree in Law at the Universidad de Salamanca, where he became Rector at the early age of twenty-three years old. The position allowed him to stay in touch with relevant characters from Madrid, although it also brought him into conflicts with the Minister of Grace and Justice, which momentarily banned his entry into the high administration of the Kingdom. In 1808, when King Charles IV abdicated, he was in the Iberian Peninsula, so once the Junta Central was constituted, he became the government representative of the province of León. When the Council of Regency was formed, he was appointed Minister of the Council of Spain and the Indies, and participated in some actions against the French.

In 1810, he was elected Royal Commissioner for the reorganization of Santo Domingo after his reincorporation into the Spanish administration; he maintained a conservative stance characterized by the recovery of the institutions and laws of 1795. He was accused of favoring his relatives and members of the Dominican elite who had not participated in the resistance against the French. He was also the promoter of the candidacy of his uncle, Adrián María Campuzano, as government representative of Santo Domingo. In 1811, he returned to Spain, where he once again was named Minister. In 1813, he was elected government representative, a position that he held again as an alternate representative in 1820 and 1821. His work there was characterized by a low activity to avoid confrontation with the more liberal parliamentarians, and his active participation in the committees.

With the return of King Ferdinand VII in 1814, he aligned himself with the most conservative and absolutist ideas and entered the government as a minister of the Supreme Council of the Indies; from 1820 to 1830 he occupied a seat on the Supreme Court of Justice, and in 1830, he was elected Minister of the Council of the Cámara de Indias. His political prominence survived during the regency of Maria Cristina, first as a member of the Governing Council and, from 1834, due to the publication of the Royal Statute, as the dignitary of the Kingdom. He still maintained political activity in the following years, although his diminished health was affecting the intensity of it.